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1Division of Dermatology, Kobe University Graduate School of Medicine, Kobe, Japan2Division of Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan3Department of Systems Biology, Graduate School of Pharmacological Science, Kyoto University, Kyoto, JapanCorrespondence: Dr Hitoshi Okamura, Department of Systems Biology, Graduate School of Pharmacological Science, Kyoto University, 46-29 Yoshida-Shimo-Adachi-cho, Sakyo-ku, Kyoto 606-8501, Japan. In this study, we demonstrated that nike free run expression of the clock and clock-controlled genes showed robust rhythms in mouse skin under constant dark conditions, whereas these rhythms were completely lost in Cry1 knockout mice lacking a molecular clock. These findings demonstrate that the intrinsic oscillating molecular clock exists in the epidermis, and that signaling from the SCN is essential for the maintenance of the epidermal clock, and cannot be compensated by external light..
(Photo by Joel Ryan/Invision/AP) (British actor Jeremy Irvine poses during a photo call after announcing the nominations for the EE British Academy Film Awards in 2013 at BAFTA Headquarters in Piccadilly, central London, Wednesday, Jan. 9, 2013. (Photo by Joel Ryan/Invision/AP)).
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